Sigma (σ) receptor ligand, AC927 (N-phenethylpiperidine oxalate), attenuates methamphetamine-induced hyperthermia and serotonin damage in mice

►AC927 alone has no significant effects on striatal serotonin levels, striatal serotonin transporter expression, or body temperature. ►AC927 attenuates methamphetamine-induced hyperthermia at ambient, room temperature. ►AC927 attenuates methamphetamine-induced neurotoxicity as measured as reductions in striatal serotonin levels and serotonin transporter expression. ►There is a significant correlation between body temperature and striatal serotonin levels. ►At high ambient temperature, AC927 attenuates methamphetamine-induced lethality, but does not reduce body temperature to saline-like levels.