Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

►JNJ16259685 had a mild disruption of motor function in rodents. ►Effects were at doses that are higher than required for anxiolytic-like efficacy. ►The effects are more profound in mouse than in rat. ►The species difference is not explained by differences in exposure. ►JNJ16259685 has a larger impact on motor learning.