Differential effects of total sleep deprivation on contextual and spatial memory: Modulatory effects of modafinil

► Development of an original sleep deprivation (SD) model with low stress component. ► SD induced hippocampal-dependent contextual but not spatial memory retrieval deficit. ► Modafinil dose-dependently reversed the contextual memory deficit of SD animals. ► Modafinil restores hippocampal-dependent memory function.