The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat

► Blocking endogenous cannabinoid signaling at CB1 receptors reduces weight gain. ► AM4113 induces a transient inhibition of food intake. ► Inhibition of weight gain is due to reduced food intake not changes in metabolism. ► Chronic AM4113 treatment alters neither brain nor plasma 2-AG levels.