کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10838448 | 1067167 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519 Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519](/preview/png/10838448.png)
چکیده انگلیسی
In the present study, we evaluated delayed treatment effects of the proteasome inhibitor and anti-inflammatory agent MLN519 (initiated 10 h post-injury) to improve recovery following ischemic brain injury in rodents. Male rats were exposed to 2 h of middle cerebral artery occlusion (MCAo) and treated with MLN519 (1.0 mg/kg, i.v. @ 10, 24, and 48 h post-occlusion) or vehicle. By 2 weeks post-injury, 60% (6 / 10) of vehicle animals survived, which was improved (although non-significantly) to 78% (7 / 9) following MLN519 treatment. The percent loss of tissue in the ipsilateral brain hemisphere (at 2 weeks) was significantly reduced from 27 ± 4% (vehicle) to 15 ± 4% (MLN519). MLN519 treated animals also lost significantly less body weight (39%) and showed significant improvement in overall neurological function across the 2-week recovery period. However, no significant treatment effects were observed to reduce foot-fault deficits (balance beam) or improve recovery of operant performance (active avoidance test). Overall, delayed treatment with MLN519 provided significant improvement in 3 of 6 test metrics (histopathology, body weight, and neurological dysfunction) supporting improved outcome for brain-injured subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 1, May 2005, Pages 182-189
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 1, May 2005, Pages 182-189
نویسندگان
Anthony J. Williams, Todd M. Myers, Scott I. Cohn, Keith M. Sharrow, Xi-Chun M. Lu, Frank C. Tortella,