کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10838585 | 1067172 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of PKC in basolateral amygdala and posterior parietal cortex impairs consolidation of inhibitory avoidance memory
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Hippocampal α- and βI/βII protein kinase C (PKC) are crucial for the formation of different types of memory in several species, including that for a one trial inhibitory avoidance (IA) task in rats. Many studies, however, have shown that other brain structures besides the hippocampus, notably the basolateral amygdala (BLA) and posterior parietal cortex (PC) are also necessary for memory consolidation. Here, we examine the role of α- and βI/βII PKC in the BLA and PC on the consolidation of the memory for IA in rats. The selective inhibitor of α- and βI/βII-PKC Gö 6976 and the nonselective PKC inhibitor Gö 7874 were administered into these structures at different times after training at concentrations known to inhibit PKC and to produce retrograde amnesia when given into the hippocampus. Gö 7874 blocked consolidation of IA memory when infused into BLA immediately and 30 min or into PC 180 to 360 min posttraining. Gö 6976 caused amnesia when given into the BLA also immediately or 30 min posttraining but in the PC hindered memory retention only when infused 270 and 360 min after the training session. Our data indicate that α- and βI/βII-PKC are critical for consolidation of IA memory shortly after training in BLA and that, first other isoforms and subsequently the α- and βI/βII PKC are required 3 or more hours after training in the PC. The findings on BLA are similar to those previously reported in the hippocampus, but those on PC suggest an entirely different molecular dynamics for memory formation in that area.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 80, Issue 1, January 2005, Pages 63-67
Journal: Pharmacology Biochemistry and Behavior - Volume 80, Issue 1, January 2005, Pages 63-67
نویسندگان
Juliana S. Bonini, MartÃn Cammarota, Daniel S. Kerr, Lia R.M. Bevilaqua, Iván Izquierdo,