Expression and characterization of a novel scorpine-like peptide Ev37, from the scorpion Euscorpiops validus

► The first scorpion toxin of Euscorpiidae family was identified by cDNA method. ► The novel toxin Ev37 was a new member of scorpine-like peptide. ► Ev37 and its truncated peptides were expressed and purified in E. coli system. ► The rEv37 peptide selectively inhibited Kv1.3 channel current. ► The truncated N-terminal or C-terminal domain of Ev37 did not block Kv1.3 channel.