کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10845275 | 1069439 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced neurogenesis in the rat hippocampus following high fructose consumption
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reduced neurogenesis in the rat hippocampus following high fructose consumption Reduced neurogenesis in the rat hippocampus following high fructose consumption](/preview/png/10845275.png)
چکیده انگلیسی
In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 167, Issue 1, 25 February 2011, Pages 26-30
Journal: Regulatory Peptides - Volume 167, Issue 1, 25 February 2011, Pages 26-30
نویسندگان
Karin van der Borght, Rickard Köhnke, Nathanael Göransson, Tomas Deierborg, Patrik Brundin, Charlotte Erlanson-Albertsson, Andreas Lindqvist,