Bradykinin and prostaglandin E1 regulate calcitonin gene-related peptide expression in cultured rat sensory neurons

► BK and PGE1 stimulate long-term expression and release of CGRP in cultured DRG neurons. ► The effect of BK was mediated completely through the BK B2 receptor. ► The effect of BK was mediated by a cyclooxygenase product(s).