کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870463 1074002 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors
چکیده انگلیسی
Human D-type prostanoid (DP) and E-type prostanoid 2 (EP2) receptors are regarded as the most closely related receptors among prostanoid receptors. Although these receptors are generated by tandem duplication, their physiological outputs often oppose one another. In the present study, we extracted mutations occurring in the coding regions of both receptors using the 1000 genome project database and found that EP2 receptors have 8-fold fewer amino acid mutations. We speculate that EP2 receptors exhibit more constraints to mutations than DP receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 6, 12 March 2015, Pages 766-772
نویسندگان
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