کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870606 1074014 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21
چکیده انگلیسی
Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss-of-function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP-mediated phenotypic induction of osteoclast differentiation accompanied by p21 down-regulation, attenuating the proliferation of osteoclast precursor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 21, 3 November 2014, Pages 4026-4031
نویسندگان
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