کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872730 | 1074246 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions](/preview/png/10872730.png)
چکیده انگلیسی
To examine the effect of aggregation sequence QGGYQQQYNP from yeast Sup35 on fibril formation of sperm whale apomyoglobin (apoMb), we constructed several mutants via substitution. Urea-induced unfolding of apoMb confirms that the substitution of the aggregation sequence does not significantly affect the stability of the mutants compared to wild type (WT) at pH 4.2. Under this condition, however, despite the difference in rate most apoMb mutants form fibrils more readily than WT with distinct morphology. These results suggest that the aggregation sequence facilitates fibril assembly of apoMb at acidic pH in vitro and this facilitation depends on the regions replaced.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 6, 28 February 2005, Pages 1503-1508
Journal: FEBS Letters - Volume 579, Issue 6, 28 February 2005, Pages 1503-1508
نویسندگان
Yingbo He, Huadong Tang, Zhiwei Yi, Hao Zhou, Yongzhang Luo,