کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1087512 951533 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2,3,7,8-Tetrachlorodibezo-p-dioxin exposure and prostate cancer: a meta-analysis of cohort studies
ترجمه فارسی عنوان
قرار گرفتن در معرض 2،3،7،8-تترا کلریدیبوزوپتوفان دیوکسین و سرطان پروستات: یک متاآنالیز مطالعات کوهورت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
چکیده انگلیسی

ObjectiveTo perform a meta-analysis of cohort studies and evaluate the association between exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and prostate cancer quantitatively.Study designPublications before April 2012 about populations exposed to TCDD were searched in PubMed. Only cohort studies were included. Extraction and quality assessment of included articles was performed independently by two authors using the MOOSE guidelines.MethodsA total of 17 cohort studies on prostate cancer with information about standardized mortality ratios (SMR), risk ratio (RR), standardized incidence ratios (SIR) and TCDD exposure were included. SMRs and RRs were pooled separately after weighing each study by calculating the inverse of the estimated variance.ResultsBased on the 13 reported SMRs or SIRs, the meta-analysis yielded a meta-SMR of 1.26 (95% confidence interval 1.00–1.57, P = 0.046). The meta-RR, based on four reported RR from four cohorts, was 1.04 (95% confidence interval 0.85–1.28). Begg's funnel plot showed little evidence of publication bias (Egger's test P-value = 0.817).ConclusionThis meta-analysis suggests that exposure to TCDD is associated with increased risk of prostate cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Public Health - Volume 128, Issue 3, March 2014, Pages 207–213
نویسندگان
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