کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10884855 | 1079563 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses
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کلمات کلیدی
GC3SORFRSCUH5N1ENc - ENCS.D. - SD.Synonymous codon usage - استفاده از کدون مترادفRelative Synonymous Codon Usage - استفاده کادون مترادف نسبیstandard deviation - انحراف معیارCorrespondence analysis - تجزیه و تحلیل نامهEffective number of codons - تعداد موثر کدون هاMutational bias - تعصب موتاسیونbase pair - جفت پایهSelection pressure - فشار انتخابopen reading frame - قاب خواندن بازGC content - محتوای GCInfluenza A virus - ویروس آنفولانزا A
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, we calculated the codon usage bias in H5N1 virus and performed a comparative analysis of synonymous codon usage patterns in H5N1 virus, five other evolutionary related influenza A viruses and a influenza B virus. Codon usage bias in H5N1 genome is a little slight, which is mainly determined by the base compositions on the third codon position. By comparing synonymous codon usage patterns in different viruses, we observed that the codon usage pattern of H5N1 virus is similar with other influenza A viruses, but not influenza B virus, and the synonymous codon usage in influenza A virus genes is phylogenetically conservative, but not strain-specific. Synonymous codon usage in genes encoded by different influenza A viruses is genus conservative. Compositional constraints could explain most of the variation of synonymous codon usage among these virus genes, while gene function is also correlated to synonymous codon usages to a certain extent. However, translational selection and gene length have no effect on the variations of synonymous codon usage in these virus genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 81, Issue 1, July 2005, Pages 77-86
Journal: Biosystems - Volume 81, Issue 1, July 2005, Pages 77-86
نویسندگان
Tong Zhou, Wanjun Gu, Jianmin Ma, Xiao Sun, Zuhong Lu,