کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10915440 | 1090060 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of 23Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors
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کلمات کلیدی
MRSWSSFOVDWISNRRDWICPRECSADCRIF-1nuclear magnetic resonance - رزونانس مغناطیسی هستهایH&E - H & E[Na+]i - [Na +] IMRI - امآرآی یا تصویرسازی تشدید مغناطیسیNMR - تشدید مغناطیسی هستهای diffusion-weighted images - تصاویر توزیع شده وزنMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیminimum essential medium - حداقل حداقل مورد نیازintraperitoneal - داخل صفاقیecho time - زمان اکوRepetition time - زمان تکرارsubcutaneous - زیر جلدیSodium - سدیم Cyclophosphamide - سیکلوفسفامید Chemotherapy - شیمیدرمانیapparent diffusion coefficient - ضریب انتشار آشکارmagnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسیIntracellular sodium concentration - غلظت سدیم داخل سلولیMEM - مامانField of view - میدان دیدSignal-to-noise ratio - نسبت سیگنال به نویزHematoxylin and Eosin - هماتوکسیلین و ائوزینDiffusion - واپخش یا انتشار inductively coupled plasma - پلاسما جفتشده القایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Application of 23Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors Application of 23Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors](/preview/png/10915440.png)
چکیده انگلیسی
Effects of an alkylating anticancer drug, cyclophosphamide (Cp), on 23Na signal intensity (23Na SI) and water apparent diffusion coefficient (ADC) were examined in subcutaneously - implanted radiation-induced fibrosarcoma (RIF-1) tumors by in vivo23Na and 1H magnetic resonance imaging (MRI). MRI experiments were performed on untreated control (n = 5) and Cp-treated (n = 6) C3H mice, once before Cp injection (300 mg/kg) then daily for 3 days after treatment. Tumor volumes were significantly lower in treated animals 2 and 3 days posttreatment. At the same time points, MRI experiments showed an increase in both 23Na SI and water ADC in treated tumors, whereas control tumors did not show any significant changes. The correlation between 23Na SI and water ADC changes was dramatically increased in the Cp-treated group, suggesting that the observed increases in 23Na SI and water ADC were caused by the same mechanism. Histologic sections showed decreased cell density in the regions of increased 23Na and water ADC SI. Destructive chemical analysis showed that Cp treatment increased the relative extracellular space and tumor [Na+]. We conclude that the changes in water ADC and 23Na SI were largely due to an increase in extracellular space. 23Na MRI and 1H water ADC measurements may provide valuable noninvasive techniques for monitoring chemotherapeutic responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 7, Issue 7, July 2005, Pages 658-666
Journal: Neoplasia - Volume 7, Issue 7, July 2005, Pages 658-666
نویسندگان
Andriy M. Babsky, Shahryar K. Hekmatyar, Hong Zhang, James L. Solomon, Navin Bansal,