کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10927114 | 1092389 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo](/preview/png/10927114.png)
چکیده انگلیسی
We previously reported that Vβ3+ CD4+ T cells maintained a protracted expansion, with the phenotypes of memory Th2 cells, for 30 days in C57BL/6 (B6) mice implanted with SEA-containing mini-osmotic pumps. In the present study, we followed the fate of Vβ3+ CD4+ T cells in CD28â/â mice. Vβ3+ CD4+ T cells increased to a degree similar to that of B6 Vβ3+ CD4+ T cells until day 10 after implantation, then declined rapidly reaching the control level by 28 days. Remaining Vβ3+ CD4+ T cells at that time did not exhibit memory phenotypes nor Th2-deviated responses. The rapid drop in Vβ3+ CD4+ T cells in CD28â/â mice was attributable to upregulated induction of apoptosis owing to marginal inductions of Bcl-2 and Bcl-xL. Collectively, these data indicate CD28 to play critical roles in the generation and maintenance of SEA-reactive CD4+ T cells in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 238, Issue 2, December 2005, Pages 103-112
Journal: Cellular Immunology - Volume 238, Issue 2, December 2005, Pages 103-112
نویسندگان
Kenji Fukada, Madoka Koyanagi, Yutaka Arimura, Hideki Ogiuchi, Takehiko Uchiyama, Junji Yagi,