کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940809 | 1095513 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lower activation-induced T-cell apoptosis is related to the pathological immune response in secondary infection with hetero-serotype dengue virus
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کلمات کلیدی
TGF-βIFN-γAPCAICDADEqRT-PCRRT-PCRBFATCrDENVDSSDHFPBMCCFSEFACSMOI - MEantigen-presenting cell - آنتیژن ارائه سلولenzyme linked immunosorbent assay - آنزیم تست ایمونوسیورسانس مرتبط استAntibody dependent enhancement - افزایش وابستگی آنتی بادیbrefeldin A - برفلدین ADengue hemorrhagic fever - تب خونریزی دهنده دنگDengue fever - تب دنگیTransforming Growth Factor Beta - تبدیل بتا فاکتور رشدELISA - تست الیزاtumor necrosis factor-alpha - تومور نکروز عامل آلفاApoptosis - خزان یاختهایstandard error of the mean - خطای استاندارد میانگینRoom temperature - دمای اتاقreal-time reverse-transcription polymerase chain reaction - زمان واقعی واکنش زنجیره ای پلیمراز معکوس رونویسیPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیT cell - سلول تیDendritic cell - سلول دندریتیکDengue shock syndrome - سندرم شوک دنگیSecondary infection - عفونت ثانویهTNF-α - فاکتور نکروز توموری آلفاSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیactivation-induced cell death - مرگ سلولی ناشی از فعال شدنquantitative reverse-transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی معکوس رونویسیDengue virus - ویروس دنگیpost-infection - پس از عفونتmultiplicity of infection - چندین عفونتcarboxyfluorescein succinimidyl ester - کربوکسیفلوورسسین سوکسینیمیدیل استرInterferon gamma - گاما اینترفرونT cell receptor - گیرنده سلول T
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lower activation-induced T-cell apoptosis is related to the pathological immune response in secondary infection with hetero-serotype dengue virus Lower activation-induced T-cell apoptosis is related to the pathological immune response in secondary infection with hetero-serotype dengue virus](/preview/png/10940809.png)
چکیده انگلیسی
The available evidence suggests that dengue virus-specific T lymphocytes and cytokine storm play a pivotal role in the immunopathogenesis of plasma leakage. Investigations are underway to identify the immune profiles associated with increased or decreased risk for severe disease. In this study, CD14+ cells from the peripheral blood mononuclear cells (PBMCs) of patients who recovered from DENV-1 infection were infected with DENV-1 or DENV-2 and co-cultured with memory T cells. We found that secondary infection with DENV-2 suppresses the cell reproductive capacity but forms more cell clones and more functional cells to produce more proinflammatory factors (IFN-γ, TNF-α, IL-6, IL-8, IL-12 and IL-17) and less regulatory cytokines (IL-10, TGF-β) which results in higher viral replication compared to secondary infection with DENV-1. Memory dengue virus-specific T cells which are induced in a primary dengue virus infection are reactivated by the heterologous serotype of dengue virus and antigen-presenting cells (APCs) during a secondary infection. Dramatically, less apoptosis and more continuous activation of T cells in secondary infection with hetero-serotype DENV were observed. This discovery which has not been reported previously may be the reasonable and vital interpretation for the cytokine storm and severe symptoms observed in secondary infection with DENV. In summary, secondary infection with hetero-serotype DENV elicits the relatively pathological immune response while secondary infection with homologous-serotype DENV induces the relatively protective immune response by activation-induced cell death (AICD) of T cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 221, Issue 3, March 2016, Pages 432-439
Journal: Immunobiology - Volume 221, Issue 3, March 2016, Pages 432-439
نویسندگان
Wang Yang, Huacheng Yan, Yuling Ma, Tiantian Yu, Hongxia Guo, Yuchan Kuang, Ruiwen Ren, Jintao Li,