Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: From contractility to remodeling

► cGMP is an important intracellular second messenger in cardiac myocytes. ► cGMP signaling specificity through compartmentalization of synthesis and hydrolysis. ► cGMP signals cross-talk with cAMP signals through phosphodiesterases. ► cGMP-dependent signaling pathways inhibit cardiac remodeling.