کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956104 | 1098784 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardioprotection of 17β-estradiol against hypoxia/reoxygenation in cardiomyocytes is partly through up-regulation of CRH receptor type 2
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کلمات کلیدی
CRHR2UrocortinsUCNEREsIPCIHDRIA17β-estradiol - 17β استرادیولH/R - H / RMTT - MTTischemic preconditioning - preconditioning ایسکمیکSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNASp1 - SP1Estrogens - استروژنUrocortin - اوروکورتینischemic heart disease - بیماری قلبی ایسکمیکradioimmunoassay - رادیوایمونواسیCardiomyocytes - قلب و عروقlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH methyl thiazolyl tetrazolium - متیل تیزولیل تترازولیمhypoxia/reoxygenation - هیپوکسیا / اکسیداسیون مجددSpecific protein 1 - پروتئین خاص 1Estrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cardioprotection of 17β-estradiol against hypoxia/reoxygenation in cardiomyocytes is partly through up-regulation of CRH receptor type 2 Cardioprotection of 17β-estradiol against hypoxia/reoxygenation in cardiomyocytes is partly through up-regulation of CRH receptor type 2](/preview/png/10956104.png)
چکیده انگلیسی
Estrogens have been suggested to exert cardioprotection through maintaining endogenous cardioprotective mechanisms. In the present study, we investigated whether estrogens protect cardiomyocytes against hypoxia/reoxygenation (H/R) via modulating urocortins (UCNs) and their receptor corticotrophin-releasing hormone receptor type 2 (CRHR2). We found that 17β-estradiol (E2) enhanced UCN cardioprotection against H/R and increased CRHR2 expression in neonatal rat cardiomyocytes. E2 protected cardiomyocytes against H/R, which was impaired by CRHR2 antagonist or knockdown of CRHR2. Estrogen receptor α (ERα) antagonist treatment or ERα knockdown could abolish E2-induced CRHR2 up-regulation. Moreover, knockdown of Sp1 also attenuated E2-induced CRHR2 up-regulation. Ovariectomy resulted in down-regulation of CRHR2 and Sp-1 in myocardium of mice, which was restored by E2 or ERα agonist treatment. These results suggest that estrogens act on ERα to up-regulate CRHR2 expression in cardiomyocytes, thereby enhancing cardioprotection of UCNs against H/R.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 382, Issue 1, 25 January 2014, Pages 17-25
Journal: Molecular and Cellular Endocrinology - Volume 382, Issue 1, 25 January 2014, Pages 17-25
نویسندگان
Binhai Cong, Yongjun Xu, Hui Sheng, Xiaoyan Zhu, Long Wang, Wei Zhao, Zhiping Tang, Jianqiang Lu, Xin Ni,