BMP action in the pituitary: Its possible role in modulating somatostatin sensitivity in pituitary tumor cells

► BMPs elicit differential actions in PRL and ACTH regulation. ► BMPs modulate SSTR sensitivity of lactosomatotrope cells in an autocrine/paracrine manner. ► SSTR action increases BMP receptor signal in corticotrope cells. ► The interaction of BMPR and SSTR actions is crucial for the tolerance to somatostatin analogs. ► Control of SSTR sensitivity may be a future strategy for aggressive pituitary tumors.