Zalpha-domains: At the intersection between RNA editing and innate immunity

► The A to I RNA editing modification has a regulatory role in innate immunity. ► The RNA editing enzyme ADAR1 increases viral proliferation. ► Distinguishing feature of ADAR1 is a Z-DNA/Z-RNA binding domain, Zalpha. ► Zalpha domains characterize proteins of the interferon response involved in the recognition of foreign nucleic acids.