کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971703 | 1106514 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NOD-like subfamily of the nucleotide-binding domain and leucine-rich repeat containing family receptors and their expression in channel catfish
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PRRLRRnucleotide-binding oligomerization domain containing 2NLRC5NALPIctalurus punctatusNOD2NOD1NLRPAMPNLRX1IPAFNLRC3PYDNODBIR - BRCIITA - CITpathogen-associated molecular pattern - الگوی مولکولی وابسته به پاتوژنPathogen recognition - تشخیص پاتوژنleucine-rich repeat - تکرار غنی از لوسینnucleotide-binding oligomerization domain - دامنه oligomerization اتصال دهنده نوکلئوتیدcaspase recruitment domain - دامنه استخدام کاسپسNACHT - شبFish - ماهیImmunity - مصونیتDisease resistance - مقاومت در برابر بیماریPyrin - من سعی کنیدNAIP - نایپNeuronal apoptosis inhibitory protein - پروتئین مهار کننده آپوپتوز عصبیCARD - کارتCatfish - گربه ماهیReceptor - گیرنده pattern recognition receptor - گیرنده شناسایی الگو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: NOD-like subfamily of the nucleotide-binding domain and leucine-rich repeat containing family receptors and their expression in channel catfish NOD-like subfamily of the nucleotide-binding domain and leucine-rich repeat containing family receptors and their expression in channel catfish](/preview/png/10971703.png)
چکیده انگلیسی
The NLRs (nucleotide-binding domain and leucine-rich repeat containing family receptors) are a recently identified family of pattern recognition receptors in vertebrates. Several subfamilies of NLRs have been characterized in human, mouse, and zebrafish, but studies of NLRs in other species, especially teleost species, have been lacking. Here we report characterization of five NLRs from channel catfish: NOD1, NOD2, NLRC3, NLRC5, and NLRX1. Structural analysis indicated that the genes were organized in a similar fashion as in the mammals and in zebrafish. Phylogenetic analysis suggested that they were orthologous to the NOD-like subfamily of NLRs. All five NOD-like genes exist as a single copy gene in the catfish genome. Hybridization of gene-specific probes allowed mapping of three NLR genes to the catfish physical map, laying a foundation for genome characterization and for establishing orthologies with NLR genes from other species. These genes are widely expressed in various tissues and leukocyte cell lines. While the majority of the NLR genes appeared to be constitutively expressed, NOD1 was induced after infection with a bacterial pathogen, Edwardsiella ictaluri, the causative agent of enteric septicemia of catfish (ESC), suggesting its involvement in immunity against the intracellular pathogen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 33, Issue 9, September 2009, Pages 991-999
Journal: Developmental & Comparative Immunology - Volume 33, Issue 9, September 2009, Pages 991-999
نویسندگان
Zhenxia Sha, Jason W. Abernathy, Shaolin Wang, Ping Li, Huseyin Kucuktas, Hong Liu, Eric Peatman, Zhanjiang Liu,