A manganese superoxide dismutase (MnSOD) from Ruditapes philippinarum: Comparative structural- and expressional-analysis with copper/zinc superoxide dismutase (Cu/ZnSOD) and biochemical analysis of its antioxidant activities

► Molecular structural characterization of MnSOD and Cu/ZnSOD in Manila clam. ► Tissue specific expression profiles of two SODs in clam tissues. ► Transcriptional response of two SODs against poly I:C, LPS and Vibrio in gill and hemocyte. ► Biochemical analysis of antioxidant activity of MnSOD protein using xanthine/XOD assay.