A model for the progression of receptor-ligand interactions during erythrocyte invasion by Plasmodium falciparum

► Entry of malaria merozoites into erythrocytes is preceded by a ∼10 s pre-invasion phase. ► Pre-invasion concludes with the formation of a junction at the host-parasite interface where AMA1 binds the RON complex. ► Binding of EBL/PfRh ligands to their erythrocyte receptors may help orientate the merozoite apex to the erythrocyte surface. ► The binding of merozoite ligand PfRh5 to the erythrocyte Basigin receptor is an essential pre-invasion step.