Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation

► Ancylostoma caninum heat shock factor binding protein, Ac-HSB-1, is orthologous to Caenorhabditis elegans (Ce)-HSB-1. ► Ac-HSB-1 interacts with heat shock factor of C. elegans only during heat shock. ► Heat shock, but not host-like temperatures, down-regulates Ac-hsb-1 expression. ► Larval activation increases Ac-hsb-1 expression.