Miltefosine, a promising novel agent for schistosomiasis mansoni

► Miltefosine is effective against the different developmental stages of Schistosoma mansoni. ► Miltefosine is effective in a multiple dose regimen course for 5 days. ► Miltefosine is a promising lead compound for synthesis of novel anti-schistosomal derivatives. ► Miltefosine can be used as an alternative anti-schistosomal agent whenever resistance to praziquantel is reported.