کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11010640 | 1807145 | 2018 | 54 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro⢠(New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments
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کلمات کلیدی
ALTDMAATLDAAPAPUPLCqRT-PCRNDIHDSDMSO - DMSOAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Drug-induced liver injury - آسیب کبدی ناشی از مواد مخدرAlanine aminotransferase - آلانین آمینوترانسفرازAcetaminophen - استامینوفن MED - باDILI - دیلیDimethyl sulfoxide - دیمتیل سولفواکسیدDILIN - زبانCardiotoxicity - سمیت قلبیHepatotoxicity - سمیت کبدDrug-Induced Liver Injury Network - شبکه های آسیب های کبدی ناشی از مواد مخدرPhytochemicals - فیتوکمیکال هاMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAquantitative real-time polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی زمان واقعی استUltra-high performance liquid chromatography - کروماتوگرافی مایع با کارایی فوق العاده بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro⢠(New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro⢠(New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments](/preview/png/11010640.png)
چکیده انگلیسی
Herbal dietary supplement (HDS)-induced hepato- and cardiotoxicity is an emerging clinical problem. In this study, we investigated the liver and heart toxicity of HDS OxyELITE-PRO⢠New Formula (OEP-NF), a dietary supplement marketed for weight loss and performance enhancement that was recently withdrawn from the market. Using a novel NZO/HlLtJ obese mouse model, we demonstrated that administration of clinically relevant mouse equivalent doses (MED) of OEP-NF produced cardio- and hepatotoxic risks following both short- and long-term administration schedules. Specifically, gavaging female NZO/HlLtJ with up to 2X MED of OEP-NF resulted in 40% mortality within two weeks. Feeding mice with either 1X or 3X MED of OEP-NF for eight weeks, while not exhibiting significant effects on body weights, significantly altered hepatic gene expression, increased the number of apoptotic and mast cells in the heart and affected cardiac function. The degree of toxicity in NZO/HlLtJ mice was higher than that observed previously in non-obese CD-1 and B6C3F1 strains, suggesting that an overweight/obese condition can sensitize mice to OEP-NF. Adverse health effects linked to OEP-NF, together with a number of other hepato- and cardiotoxicity cases associated with HDS ingestion, argue strongly for introduction of quality standards and pre-marketing safety assessments for multi-ingredient HDS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 122, December 2018, Pages 21-32
Journal: Food and Chemical Toxicology - Volume 122, December 2018, Pages 21-32
نویسندگان
Charles M. Skinner, Isabelle R. Miousse, Laura E. Ewing, Vijayalakshmi Sridharan, Maohua Cao, Haixia Lin, D. Keith Williams, Bharathi Avula, Saqlain Haider, Amar G. Chittiboyina, Ikhlas A. Khan, Mahmoud A. ElSohly, Marjan Boerma, Bill J. Gurley,