Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis

These results provide transcriptomic evidence that deregulated JNK signaling may impair collagen synthesis in osteoblasts and imply a therapeutic value of JNK inhibitors for treating osteoporosis and preventing skeletal aging by counteracting the age-related reduction in the function of osteoblasts.