کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11019350 | 1718113 | 2018 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autism Spectrum Disorder: Classification, diagnosis and therapy
ترجمه فارسی عنوان
اختلال طیف اوتیسم: طبقه بندی، تشخیص و درمان
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کلمات کلیدی
DSMADI-RMIAPDD-NOSBPDOCDDISCOCOSSBTGADgeneralized anxiety disorder - اختلال اضطراب فراگیرbipolar disorder - اختلال دو قطبیpervasive developmental disorder - اختلال رشد فراگیرObsessive–compulsive disorder - اختلال وسواس فکریpervasive developmental disorder-not otherwise specified - اختلال پیشرفت فراگیر - در غیر اینصورت مشخص نیستattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیAutism spectrum disorder - اختلالات طیف اوتیسم گروهیComorbid disorders - اختلالات متضادchildhood-onset schizophrenia - اسکیزوفرنی شروع کننده دوران کودکیAutism - اوتیسم یا درخودماندگیoxytocin - اکسیتوسینADHD - بیشفعالیCognitive behavioral therapy - درمان رفتاری شناختیDiagnostic and Statistical Manual of Mental Disorders - راهنمای تشخیصی و آماری اختلالهای روانیCBT - رفتار درمانی شناختی Asperger's syndrome - سندرم اسپرگرTourette syndrome - سندروم تورت، سندروم تورهmaternal immune activation - فعال سازی ایمنی مادرCARS - ماشین هاAutism Diagnostic Interview-Revised - مصاحبه تشخیصی اوتیسم- اصلاح شدهChildhood Autism Rating Scale - مقیاس رتبه بندی اوتیسم دوران کودکیMusic therapy - موسیقی درمانیASD - نقص سپتوم یا دیوارهی دهلیزی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary factors, parental history of psychiatric disorders, pre-term births, and fetal exposure to psychotropic drugs or insecticides have all been linked to higher risk of ASD. Several scales such as the Childhood Autism Rating Scale (CARS), The Autism Spectrum Disorder-Observation for Children (ASD-OC), The Developmental, Dimensional, and Diagnostic Interview (3di), are available to aid in better assessing the behaviors and symptoms associated with ASD. Nearly 75% of ASD patients suffer from comorbid psychiatric illnesses or conditions, which may include attention-deficit hyperactivity disorder (ADHD), anxiety, bipolar disorder, depression, Tourette syndrome, and others. Both pharmacological and non-pharmacological interventions are available for ASD. Pharmacological treatments include psychostimulants, atypical antipsychotics, antidepressants, and alpha-2 adrenergic receptor agonists. These medications provide partial symptomatic relief of core symptoms of ASD or manage the symptoms of comorbid conditions. Non-pharmacological interventions, which show promising evidence in improving social interaction and verbal communication of ASD patients, include music therapy, cognitive behavioral therapy and social behavioral therapy. Hormonal therapies with oxytocyin or vasopressin receptor antagonists have also shown some promise in improving core ASD symptoms. The use of vitamins, herbal remedies and nutritional supplements in conjunction with pharmacological and behavioral treatment appear to have some effect in symptomatic improvement in ASD, though additional studies are needed to confirm these benefits. Developing novel disease-modifying therapies may prove to be the ultimate intervention for sustained improvement of symptoms in ASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 190, October 2018, Pages 91-104
Journal: Pharmacology & Therapeutics - Volume 190, October 2018, Pages 91-104
نویسندگان
Samata R. Sharma, Xenia Gonda, Frank I. Tarazi,