کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11021270 | 1714849 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity
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کلمات کلیدی
Resting-state functional magnetic resonance imaging - تصویربرداری رزونانس مغناطیسی عملکرد حالت حالت استراحتsingle photon emission computed tomography - توموگرافی کامپیوتری انتشار اتمی فوتونserotonin transporter - سروتونین حمل کنندهdefault mode network - شبکه حالت پیش فرضSelective serotonin reuptake inhibitor - مهار کننده بازجذب سروتونین انتخابی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The default mode network (DMN) is an important connectivity hub, and alterations may play a role in the pathophysiology of several neuropsychiatric disorders. Despite the growing body of research on DMN (dys)function, the underlying neurochemical substrate remains to be elucidated. The serotonergic neurotransmitter system has been suggested to play a substantial role in modulating the DMN. Therefore, we investigated the association between serotonin transporter (SERT) occupancy by the selective serotonin reuptake inhibitor citalopram and DMN functional connectivity. Forty-five healthy female volunteers (mean ageâ¯=â¯21.6y) participated in a double-dose study. The subjects were randomized to pre-treatment with placebo, a low (4â¯mg; 'low group') or clinically standard (16â¯mg; 'high group') oral citalopram dose (corresponding to 0%, â¼40% and â¼80% SERT occupancy, respectively). They underwent [123I]FP-CIT single-photon emission computed tomography (SPECT) imaging to assess SERT occupancy. In addition, resting-state functional magnetic resonance imaging was used to measure DMN connectivity. With non-parametric permutation testing we assessed the association between SERT occupancy and DMN connectivity. We found that SERT occupancy by citalopram was negatively associated with DMN connectivity with a number of cortical regions, including the anterior cingulate cortex (ACC), paracingulate gyrus, postcentral gyrus, superior parietal gyrus and temporal pole. These findings provide further neurochemical evidence that the serotonin system dose-dependently modulates DMN function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 28, Issue 10, October 2018, Pages 1173-1179
Journal: European Neuropsychopharmacology - Volume 28, Issue 10, October 2018, Pages 1173-1179
نویسندگان
Anouk Schrantee, Paul J Lucassen, Jan Booij, Liesbeth Reneman,