کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11025458 1686360 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liver toxicity in the era of immune checkpoint inhibitors: A practical approach
ترجمه فارسی عنوان
مسمومیت کبدی در دوران مهارکننده های بازرسی ایمنی: رویکرد عملی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Immune checkpoint inhibitors have revolutionized the cancer treatment with an approved efficacy in different solid tumors and hematologic malignancies. These agents are increasing the indication in cancer treatment, but can be associated with serious immune-related adverse effects (IRAEs). Dermatologic and gastrointestinal toxicities are the most common IRAE followed by endocrinopathies with a different time of occurrence. Rarely cases of gastrointestinal toxicities are observed almost 2 years after initiation of the therapy. In this review we focus on liver toxicity related to these immunotherapeutic agents for which the largest amount of safety data is available. The management of drug-induced liver toxicity is very complicated and in same cases may take a long period of time to be resolved. A prompt recognition of liver IRAEs and an appropriate management of this event, requiring close collaboration with other specialist figures, could improve its treatment with evident implication on the efficacy of the therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 132, December 2018, Pages 125-129
نویسندگان
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