کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11027075 | 1666324 | 2019 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of a 1:1.5 cocrystal of kaempferol with 4,4â²-bipyridine based on analyzing intermolecular interaction of building units
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Based on analyzing intermolecular interaction in building unit of cocrystal of quercetin with 4,4â²-bipyridine (QUE·BPY) reported by us on before, a new cocrystal of kaempferol with 4,4â²-bipyridine (KAE·BPY) has been designed and synthesized. Within the reported QUE·BPY, 3â²OH was neither involved in the formation of the building unit nor played a big role in the 2D layer. Consequently, we boldly speculate kaempferol without 3â²OH might crystallize with 4,4â²-bipyridine to form similar structure to QUE·BPY. Just as expected, structural analysis shows kaempferol molecules and 4,4â²-bipyridine molecules alternate connect to form the building units through 7-OH and 4â²OH hydrogen bonds, the structure of KAE·BPY is similar to QUE·BPY. This work proves that new cocrystals could be designed and synthetized by analyzing the intermolecular interaction in building unit and seeking right structure of Active Pharmaceutical Ingredients (APIs). Additionally, the cocrystal of kaempferol with 4,4â²-bipyridine shows advantages in terms of hygroscopic stability in comparison to pure kaempferol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1177, 5 February 2019, Pages 107-116
Journal: Journal of Molecular Structure - Volume 1177, 5 February 2019, Pages 107-116
نویسندگان
Xin Su, Yu-nan Zhang, He-mei Yin, Li-xin Liu, Yu Zhang, Li-li Wu, Qiang Zhang, Chao-xing Wang, Lei Zhang, Yun-jie Zhang, Yao-xin Zhang,