کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11027382 | 1666299 | 2018 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolomic profile of Schinopsis brasiliensis via UPLC-QTOF-MS for identification of biomarkers and evaluation of its cytotoxic potential
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Schinopsis brasiliensis is a plant typically found in the caatinga biome (northeastern Brazil). Its leaves and bark have been used for the treatment of health dysfunctions such as cough, influenza, diarrhea, throat inflammation, and sexual impotence. However, there is a lack of knowledge regarding the chemical composition and pharmacological activities of this plant. High-performance liquid chromatography coupled to high-resolution mass spectrometry (UPLC-QTOF-MSE) allowed the partial identification of 33 compounds, including isomers from leaf, branch, and bark samples, with 16 compounds reported for the first time (corilagin, chlorogenic acid, and quercetin derivatives) in S. brasiliensis. Principal component analysis efficiently distinguished the respective parts of the plant. Orthogonal partial least squares discriminatory analysis, together with the variable importance in projection and S-Plot graphs were used to identify 23 biomarker compounds associated with cytotoxic activity against a colorectal cancer cell line.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 1099, 1 November 2018, Pages 97-109
Journal: Journal of Chromatography B - Volume 1099, 1 November 2018, Pages 97-109
نویسندگان
Licia dos Reis Luz, Diogo Denardi Porto, Caio B. Castro, Maria Francilene S. Silva, Elenilson de Godoy Alves Filho, Kirley Marques Canuto, Edy Sousa de Brito, Helena Becker, Claúdia do à Pessoa, Guilherme Julião Zocolo,