Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine

A new asymmetric zinc phthalocyanine conjugated with triazatricyclodecane (3) was synthesized. Upon methylation to compound 4, the agent exhibited potent anti-bacterial activity with an IC50 value at nano-molar range and >4 logs reduction of bacteria load.161