Cadmium induced redistribution of cholesterol by upregulating ABCA1 and downregulating OSBP

Cadmium (Cd) induced cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) accumulation through inhibiting lysosomal pathways by disrupting its acidic environment of lysosomes and autolysosomes and autophagic flux. And Cd also increased oxysterol-binding protein (OSBP) degradation by increasing ubiquitination. Cd induced ABCA1 accumulation and OSBP degradation facilitated cholesterol excretion.243