Electroanalysis of antitubercular drugs in pharmaceutical dosage forms and biological fluids: A review

• A review on the determination of antitubercular drugs is presented.
• Electrochemical methods explored during 2006 – present for the determination are summarized.
• A comparison of electrochemical methods and chromatographic methods is presented.

Tuberculosis remains a major global public health problem. Given the need for extensive analysis of antitubercular drugs, the development of sensitive, reliable and facile analytical methods to determine these compounds becomes necessary. Electrochemical techniques have inherent advantages over other well-established analytical methods, this review aiming to provide an updated overview of the latest trends (from 2006 till date) in the voltammetric determination of antitubercular drugs. Furthermore, the advantages and limitations of these methods are critically discussed. The review reveals that in spite of using a variety of chemically modified electrodes to determine antitubercular drugs, there is still a dearth of applicability of the voltammetric methods to quantify these compounds in human body fluids, especially in blood plasma.

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