کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1163972 1490962 2015 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part II
ترجمه فارسی عنوان
بررسی آموزش در مورد اعتبار سنجی روش های اسپکترومتری جرمی کروماتوگرافی مایع: قسمت دوم
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• The status of validation of LC–MS methods is comprehensively reviewed.
• Clarity is brought into validation-related terminology.
• Recommendations on difficult validation-related issues in LC–MS are given.

This is the part II of a tutorial review intending to give an overview of the state of the art of method validation in liquid chromatography mass spectrometry (LC–MS) and discuss specific issues that arise with MS (and MS–MS) detection in LC (as opposed to the “conventional” detectors). The Part II starts with briefly introducing the main quantitation methods and then addresses the performance related to quantification: linearity of signal, sensitivity, precision, trueness, accuracy, stability and measurement uncertainty. The last section is devoted to practical considerations in validation. With every performance characteristic its essence and terminology are addressed, the current status of treating it is reviewed and recommendations are given, how to handle it, specifically in the case of LC–MS methods.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 870, 22 April 2015, Pages 8–28
نویسندگان
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