کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1164365 1491002 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chiral metal–organic framework used as stationary phases for capillary electrochromatography
ترجمه فارسی عنوان
چرخه آلی فلزات کریال به عنوان فاز ثابت برای الکتروکروماتوگرافی مویرگی استفاده می شود
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• This is a report, for the first time, that the enantioseparations are carried out by MOFs in CEC.
• A novel metal–organic framework coated chiral OT capillary column was developed.
• Excellent enantioseparation for flavanone and praziquantel were achieved.
• The isomers of nitrophenols and ionones were also separated.

Metal–organic frameworks (MOFs) have received great attention as novel media in separation sciences because of their fascinating structures and unusual properties. However, to the best of our knowledge, there has been no attempt to utilize chiral MOFs as stationary phases in capillary electrochromatography (CEC). In this study, a homochiral helical MOF [Zn2(D-Cam)2(4,4′-bpy)]n (D-Cam = D-(+)-camphoric acid, 4,4′-bpy = 4,4′-bipyridine) was explored as the chiral stationary phase in open tubular capillary electrochromatography (OT-CEC) for separation of chiral compounds and isomers. The MOFs coated column has been developed using a simple procedure via MOFs post-coated on the sodium silicate layer. The baseline separations of flavanone and praziquantel were achieved on the MOFs coated column with high resolution of more than 2.10. The influences of pH, organic modifier content and buffer concentration on separation were investigated. Besides, the separations of isomers (nitrophenols and ionones) were evaluated. The relative standard deviations (RSDs) for the retention time of run-to-run, day-to-day and column-to-column were 1.04%, 2.16% and 3.07%, respectively. The results demonstrated that chiral MOFs are promising for enantioseparation in CEC.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 830, 9 June 2014, Pages 49–55
نویسندگان
, , , ,