Surface plasmon resonance sensing of nucleic acids: A review

Biosensors based on surface plasmon resonance (SPR) have become a central tool for the investigation and quantification of biomolecules and their interactions. Nucleic acids (NAs) play a vital role in numerous biological processes and therefore have been one of the major groups of biomolecules targeted by the SPR biosensors. This paper discusses the advances of NA SPR biosensor technology and reviews its applications both in the research of molecular interactions involving NAs (NA–NA, NA–protein, NA–small molecule), as well as for the field of bioanalytics in the areas of food safety, medical diagnosis and environmental monitoring.

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► Advances of nucleic acid (NA) surface plasmon resonance (SPR) sensors are presented.
► Bioanalytical applications of NA SPR biosensors are reviewed.
► Applications for study of molecular interactions involving NAs are also discussed.