A novel nonenzymatic sensor based on LaNi0.6Co0.4O3 modified electrode for hydrogen peroxide and glucose

In this paper, LaNi0.6Co0.4O3 (LNC) nanoparticles were synthesized by the sol–gel method, and the structure and morphology of LNC nanoparticles were characterized by X-ray diffraction spectrum, scanning electron microscopy and transmitting electron microscopy. And then, LNC was used to modify carbon paste electrode (CPE) without any adhesive to fabricate hydrogen peroxide and glucose sensor, and the results demonstrated that LNC exhibited strong electrocatalytical activity by cyclic voltammetry and amperometry. In H2O2 determination, linear response was obtained in the concentration range of 10 nM–100 μM with a detection limit of 1.0 nM. In glucose determination, there was the linear region of 0.05–200 μM with a detection limit of 8.0 nM. Compared with other reports, the proposed sensor also displayed high sensitivity toward H2O2 (1812.84 μA mM−1 cm−2) and glucose (643.0 μA mM−1 cm−2). Moreover, this prepared sensor was applied to detect glucose in blood serum and hydrogen peroxide in toothpaste samples with satisfied results, indicating its possibility in practical application.

CVs recorded on the bare CPE (a) and LNC/CPE (c) with 0.3 mM H2O2, LNC/CPE (b) without H2O2 in 0.1 M NaOH. Scan rate: 100 mV s−1.Figure optionsDownload as PowerPoint slideHighlights
► The sensor exhibited wide linear range and low detection limit.
► The sensor possesses high sensitivity and fast response.
► The sensor was used for detection of hydrogen peroxide and glucose.
► The proposed sensor has good stability and reproducibility.
► The sensor was applied in toothpaste and serum samples with satisfactory results.