کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1170450 1491173 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alternative calibration approaches for LC–MS quantitative determination of coeluted compounds in complex environmental mixtures using multivariate curve resolution
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Alternative calibration approaches for LC–MS quantitative determination of coeluted compounds in complex environmental mixtures using multivariate curve resolution
چکیده انگلیسی

Different calibration approaches including external calibration, standard addition and internal standard are evaluated for quantification of coeluted compounds in liquid chromatography with MS spectrometry detection in scan mode and using multivariate curve resolution. These different calibration approaches are proposed to cope with sensitivity changes and matrix effects encountered in the analysis of complex natural environmental samples. By using them, multivariate curve resolution analysis of MS data in scan mode gave similar quantitative results to those obtained by LC–MS in selected ion monitoring (SIM) mode (in both cases errors were below 16% for internal standard combined with standard addition strategy), and it provided at the same time a means of analyte confirmation via their resolved pure MS spectra, and a means to gather a larger amount of information about the whole chromatographic process and to facilitate the simultaneous determination of multiple analytes in the same chromatographic run using the same experimental and instrumental conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 595, Issues 1–2, 9 July 2007, Pages 228–237
نویسندگان
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