کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1170588 | 960685 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Telomere DNA conformation change induced aggregation of gold nanoparticles as detected by plasmon resonance light scattering technique Telomere DNA conformation change induced aggregation of gold nanoparticles as detected by plasmon resonance light scattering technique](/preview/png/1170588.png)
It has been reported that adsorption of uncoiled DNA (u-DNA) on the surface of gold nanoparticles (Au-NPs) can prevent the nanoparticle suspensions from aggregation even if in salt medium. Herein we report that quadruplex DNA (q-DNA), which is formed from uncoiled telomere DNA, via intramolecular hydrogen bonds in the presence of potassium ion, cannot keep Au-NPs stable, and the q-DNA/Au-NPs coexisting suspensions display aggregation tendency, giving plasmon resonance light scattering (PRLS) signals of Au-NPs. Mechanism investigations through a single point energy calculation on u- and q-structures of telomere DNA showed that q-DNA, compared with u-DNA, has a much higher surface negative charge density, symmetrical charge distribution and well self-structural stabilization, could not be adsorbed on the surface of Au-NPs.
Journal: Analytica Chimica Acta - Volume 604, Issue 2, 5 December 2007, Pages 165–169