Capillary gas chromatographic properties of three new mono-ester permethylated β-cyclodextrin derivatives

2I-O-Methoxycarbonylmethyl-2II-VII,3I-VII,6I-VII-eicosa-O-methyl-cyclodextrin (20Me/P2OCH2COOMe), 6I-O-methoxycarbonylmethyl-2I-VII,3I-VII,6II-VII-eicosa-O-methyl-cyclodextrin (20Me/P6OCH2COOMe), 6I-O-methoxycarbonyl-6I-deoxy-2I-VII,3I-VII,6II-VII-eicosa-O-methyl-cyclodextrin (20Me/P6COOMe) have been evaluated as chiral stationary phases (CSPs) for capillary gas chromatography. General chromatographic properties of the corresponding columns have been investigated in terms of efficiency, polarity and inertness. More than 60 solutes have been used for studying their enantioselectivity by comparison with permethylated β-cyclodextrin as a reference. Similar enantioseparation ability was established for the four studied CSPs, the 20Me/P2OCH2COOMe exhibiting in most cases a better enantioselectivity than the other selectors.