کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1177969 1491432 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of flutamide in pharmaceutical dosage using higher electrospray ionization mass spectrometry (ESI-MS) tandem mass coupled with Soxhlet apparatus
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Detection of flutamide in pharmaceutical dosage using higher electrospray ionization mass spectrometry (ESI-MS) tandem mass coupled with Soxhlet apparatus
چکیده انگلیسی

Flutamide (2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide) is a non-steroidal drug that has a specific anti-androgenic activity so that it is used in the treatment of prostate cancer. A simple method for extraction and detection of flutamide from pharmaceutical forms are reported using Soxhlet apparatus combined electrospray ionization tandem mass spectrometry (ESI(−)-MSn, n = 1−4) in negative ion mode. Spectra show a fingerprint peaks corresponding to flutamide. Propanamide moiety plays important role in structure elucidation. The diagnostic ions produced a useful fingerprint maps to identify flutamide in unknown samples. Furthermore, the proposed ions may help in the metabolite studies of the drug. The method proposed here is easy, cheap and applicable for large quantity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Chemistry Research - Volume 3, March 2015, Pages 89–97
نویسندگان
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