کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1178850 962734 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural diversity of the Y-family DNA polymerases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Structural diversity of the Y-family DNA polymerases
چکیده انگلیسی

The Y-family translesion DNA polymerases enable cells to tolerate many forms of DNA damage, yet these enzymes have the potential to create genetic mutations at high rates. Although this polymerase family was defined less than a decade ago, more than 90 structures have already been determined so far. These structures show that the individual family members bypass damage and replicate DNA with either error-free or mutagenic outcomes, depending on the polymerase, the lesion and the sequence context. Here, these structures are reviewed and implications for polymerase function are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1804, Issue 5, May 2010, Pages 1124–1135
نویسندگان
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