A mathematical model for projecting the replenishment of compounds in a sample bank

Sample banks are repositories of compounds that are screened for therapeutic potential in the drug discovery process. Effectively managing a sample bank requires good intelligence to plan the storage of compounds and the workload of personnel and equipment. We help address this concern with a mathematical model to project compound depletion and replenishment as a function of screening activity and compound copy count. The model is deterministic and formulated in terms of probabilities. Its results show good agreement with those of randomization-based simulations of sample bank operations. This suggests that the model produces reliable projections.