کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1180915 1491545 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics
چکیده انگلیسی

A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP < 2.0% and practically no bias). On the other hand, the use of “matrix-matched” standards, including the most commonly used excipients, allowed to extend the applicability of the approach also to the analysis of commercial drugs (RMSEP = 7.0%). As far as epinephrine is concerned, very accurate results were obtained (RMSEP < 2% and bias = 0.5%).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemometrics and Intelligent Laboratory Systems - Volume 133, 15 April 2014, Pages 149–156
نویسندگان
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