Preparation and Application in Tumor Cells' Drug Delivery of Gold Nanocapsule

Nanocapsules is widely used in the biomedical field because of its unique features. A new nanocapsule was prepared by using gold cage as the core, anticancer drug doxorubicin hydrochloride (DOX) as the internal filler, and functionalized DNA nanomaterials as the shell. The mouth of the cage was blocked by the functionalized DNA nanomaterials. The nanocapsule can be used for the cell detection and drug delivery. The target cells (Ramos cells) can be detected by fluorescence microscope when the drug that can act on target cells and lead to cell death was released. The nanocapsule provides a new approach for the diagnosis and treatment of tumor cells.

A new nanocapsule was prepared by using gold cage as the core, anticancer drug doxorubicin hydrochloride (DOX) as the internal filler, and functionalized DNA nanomaterials as the shell. The mouth of the cage was blocked by the functionalized DNA nanomaterials. The nanocapsule can be used for the cell detection and drug delivery. The target cells (Ramos cells) can be detected by fluorescence microscope when the drug that can act on target cells and lead to cell death was released. The nanocapsule provides a new approach for the diagnosis and treatment of tumor cells.Figure optionsDownload as PowerPoint slide