Recent Advances in Application of Nonaqueous Capillary Electrophoresis

Nonaqueous capillary electrophoresis (NACE) has been widely used in pharmaceutical, environmental, and biological analyses. A great variety of organic solvents are used in NACE, and their physical and chemical properties are different from each other. Therefore, different organic solvents can be selected for NACE according to the different analytes and the detection methods, which extends the application of capillary zone electrophoresis (CZE). In this review, the recent advances in the application of NACE were summarized, including its advantages compared with aqueous CZE, detection methods, sample preconcentration, application in real samples, and future research trends.