کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1182987 1491806 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extending the scope of neuropeptidomics in the mammalian brain
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Extending the scope of neuropeptidomics in the mammalian brain
چکیده انگلیسی


• Required increase of peptide identification coverage in neuropeptidomics.
• Neuropeptidomics applied to uncommon mammalian species.
• Quantitative neuropeptidomics for the investigation of CNS diseases and drug responses.

Neuropeptides are signaling molecules of intermediate size that are involved in neurotransmission and endocrine regulation. Complete monitoring of neuropeptides using neuropeptidomics approaches remains an important goal for describing targeted physiological regulation pathways. Considerable effort has been expended, particularly in terms of technique and methodology development, to extend the scope of neuropeptidomics. The capability of peptide characterization has been gradually improved, thus responding to increasing demands for broad detection and determination of various peptides. In this review, we discuss some achievements for the improvement of peptide identification coverage and their application for brain diseases and studying consequences of drug applications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EuPA Open Proteomics - Volume 3, June 2014, Pages 273–279
نویسندگان
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